BDBM392955 3-(4-Fluorophenyl)-7,7-dimethyl-2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one::US10301306, Example 153

SMILES: CC1(C)CNC(=O)c2c1[nH]c(c2-c1ccc(F)cc1)-c1ccncc1

InChI Key: InChIKey=OEMLSCIYEMIJRE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392955   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392955 (3-(4-Fluorophenyl)-7,7-dimethyl-2-(pyridin-4-yl)-6...) Show SMILES CC1(C)CNC(=O)c2c1[nH]c(c2-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H18FN3O/c1-20(2)11-23-19(25)16-15(12-3-5-14(21)6-4-12)17(24-18(16)20)13-7-9-22-10-8-13/h3-10,24H,11H2,1-2H3,(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair