BDBM393366 3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetidine-1-carbonitrile::US9963444, Example 67

SMILES: COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1

InChI Key: InChIKey=XWMIVCPYFUSWCV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393366 (3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetid...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H18N2O2/c1-21-17-4-2-3-16(9-17)15-7-5-14(6-8-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	0.890	n/a	n/a	n/a	n/a	n/a	n/a
Northeastern University Curated by ChEMBL					Assay Description Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay				Bioorg Med Chem 28: (2020)
					More data for this Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (Homo sapiens (Human))	BDBM393366 (3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetid...) Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1 Show InChI InChI=1S/C18H18N2O2/c1-21-17-4-2-3-16(9-17)15-7-5-14(6-8-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Institute for Medical Research					Assay Description In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...				Chem Biol Drug Des 71: 131-9 (2008) BindingDB Entry DOI: 10.7270/Q2639S2B
					More data for this Ligand-Target Pair