BDBM393801 US10597367, Example 89::US9969726, Example 89

SMILES: OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1

InChI Key: InChIKey=PVNUCWDAUWMGSN-UHFFFAOYSA-N

Data: 8 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 393801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393801 (US10597367, Example 89 | US9969726, Example 89) Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1 Show InChI InChI=1S/C22H12F4N2O3/c23-16-9-14(8-15(10-16)21(29)30)12-3-1-4-13(7-12)20-27-17(18-5-2-6-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair