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SMILES: Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1

InChI Key: InChIKey=OBCVHXRXOKTAKX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 393831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020)
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393831 (US10597367, Example 119 | US9969726, Example 119) Show SMILES Cc1cc(nc(n1)-c1cccc(c1)-c1cccc(c1)C(O)=O)-c1ccoc1 Show InChI InChI=1S/C22H16N2O3/c1-14-10-20(19-8-9-27-13-19)24-21(23-14)17-6-2-4-15(11-17)16-5-3-7-18(12-16)22(25)26/h2-13H,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	540	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair