null

SMILES: FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1

InChI Key: InChIKey=XKGRKZLUEMDLDW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 393892   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393892 (US10597367, Example 189 | US9969726, Example 189) Show SMILES FC(F)(F)c1ccc2N=C(CC(=O)Nc2c1)c1ccnc(Cl)c1 |c:8| Show InChI InChI=1S/C15H9ClF3N3O/c16-13-5-8(3-4-20-13)11-7-14(23)22-12-6-9(15(17,18)19)1-2-10(12)21-11/h1-6H,7H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair