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SMILES: Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO

InChI Key: InChIKey=YVRYQZXUTLUAIV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 393906   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM393906 (US10597367, Example 203 | US9969726, Example 203) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)C#CCO |c:4| Show InChI InChI=1S/C20H15F3N2O2/c1-12-8-17-18(10-15(12)20(21,22)23)25-19(27)11-16(24-17)14-6-2-4-13(9-14)5-3-7-26/h2,4,6,8-10,26H,7,11H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				J Med Chem 52: 1935-42 (2009) BindingDB Entry DOI: 10.7270/Q2RX9FDX
					More data for this Ligand-Target Pair