BDBM395282 N-{4-[[(4aR,5aR) or (4aS,5aS)]-3-Anilino-5a-methyl-4-oxo-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indol-2-yl]pyridin-2-yl}-2,6-difluorobenzamide::US10308629, Example 46::US10308629, Example 47
SMILES: C[C@]12C[C@H]1C(=O)c1c(C2)[nH]c(c1Nc1ccccc1)-c1ccnc(NC(=O)c2c(F)cccc2F)c1
InChI Key:
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitotic checkpoint serine/threonine-protein kinase BUB1 (Homo sapiens (Human)) | BDBM395282 (N-{4-[[(4aR,5aR) or (4aS,5aS)]-3-Anilino-5a-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE... | Bioorg Med Chem Lett 19: 3674-8 (2009) BindingDB Entry DOI: 10.7270/Q2NZ89ZG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitotic checkpoint serine/threonine-protein kinase BUB1 (Homo sapiens (Human)) | BDBM395282 (N-{4-[[(4aR,5aR) or (4aS,5aS)]-3-Anilino-5a-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE... | Bioorg Med Chem Lett 19: 3674-8 (2009) BindingDB Entry DOI: 10.7270/Q2NZ89ZG | |||||||||||
More data for this Ligand-Target Pair |