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SMILES: COCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1

InChI Key: InChIKey=ZNGQNAHACQRGPL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395287   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM395287 (N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...) Show SMILES COCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1 Show InChI InChI=1S/C18H17F3N4O3/c1-28-6-5-25-9-11-7-14(12(10-26)8-15(11)24-25)23-17(27)13-3-2-4-16(22-13)18(19,20)21/h2-4,7-9,26H,5-6,10H2,1H3,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...				US Patent US10793545 (2020)
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM395287 (N-[6-(Hydroxymethyl)-2-(2-methoxyethyl)-2H-indazol...) Show SMILES COCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1 Show InChI InChI=1S/C18H17F3N4O3/c1-28-6-5-25-9-11-7-14(12(10-26)8-15(11)24-25)23-17(27)13-3-2-4-16(22-13)18(19,20)21/h2-4,7-9,26H,5-6,10H2,1H3,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...				Bioorg Med Chem Lett 19: 3550-4 (2009) BindingDB Entry DOI: 10.7270/Q2J67K7G
					More data for this Ligand-Target Pair