BDBM395292 N-[2-(2-Hydroxyethyl)-6-(hydroxymethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide::US10308634, Example 7::US10793545, Example 7

SMILES: OCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1

InChI Key: InChIKey=UDGUXBZYVQFQBZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395292   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM395292 (N-[2-(2-Hydroxyethyl)-6-(hydroxymethyl)-2H-indazol...) Show SMILES OCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1 Show InChI InChI=1S/C17H15F3N4O3/c18-17(19,20)15-3-1-2-12(21-15)16(27)22-13-6-10-8-24(4-5-25)23-14(10)7-11(13)9-26/h1-3,6-8,25-26H,4-5,9H2,(H,22,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	867	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...				US Patent US10793545 (2020)
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM395292 (N-[2-(2-Hydroxyethyl)-6-(hydroxymethyl)-2H-indazol...) Show SMILES OCCn1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(CO)cc2n1 Show InChI InChI=1S/C17H15F3N4O3/c18-17(19,20)15-3-1-2-12(21-15)16(27)22-13-6-10-8-24(4-5-25)23-14(10)7-11(13)9-26/h1-3,6-8,25-26H,4-5,9H2,(H,22,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	867	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...				Bioorg Med Chem Lett 19: 3550-4 (2009) BindingDB Entry DOI: 10.7270/Q2J67K7G
					More data for this Ligand-Target Pair