null

SMILES: CC(C)(O)c1cc2nn(CC3COC3)cc2cc1NC(=O)c1cccc(n1)C(F)(F)F

InChI Key: InChIKey=VFSGNUGYEMFXMN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395293   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM395293 (N-[6-(2-Hydroxypropan-2-yl)-2-(oxetan-3-ylmethyl)-...) Show SMILES CC(C)(O)c1cc2nn(CC3COC3)cc2cc1NC(=O)c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C21H21F3N4O3/c1-20(2,30)14-7-16-13(9-28(27-16)8-12-10-31-11-12)6-17(14)26-19(29)15-4-3-5-18(25-15)21(22,23)24/h3-7,9,12,30H,8,10-11H2,1-2H3,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Pharma Aktiengesellschaft US Patent					Assay Description For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...				US Patent US10793545 (2020)
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM395293 (N-[6-(2-Hydroxypropan-2-yl)-2-(oxetan-3-ylmethyl)-...) Show SMILES CC(C)(O)c1cc2nn(CC3COC3)cc2cc1NC(=O)c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C21H21F3N4O3/c1-20(2,30)14-7-16-13(9-28(27-16)8-12-10-31-11-12)6-17(14)26-19(29)15-4-3-5-18(25-15)21(22,23)24/h3-7,9,12,30H,8,10-11H2,1-2H3,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...				Bioorg Med Chem Lett 19: 3550-4 (2009) BindingDB Entry DOI: 10.7270/Q2J67K7G
					More data for this Ligand-Target Pair