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SMILES: CCOC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cc2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1C

InChI Key: InChIKey=FWYCKOXFTAIFHL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 395361   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Homo sapiens (Human))		BDBM395361
PNG
(US10308636, Example 45-1)
Show SMILES CCOC(=O)c1cccc(OCC2CCN(CC2)c2ccc(cc2)-c2nc(cn2COCC[Si](C)(C)C)C(F)(F)F)c1C
Show InChI InChI=1S/C32H42F3N3O4Si/c1-6-41-31(39)27-8-7-9-28(23(27)2)42-21-24-14-16-37(17-15-24)26-12-10-25(11-13-26)30-36-29(32(33,34)35)20-38(30)22-40-18-19-43(3,4)5/h7-13,20,24H,6,14-19,21-22H2,1-5H3
PDB

UniProtKB/SwissProt

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PC cid
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US Patent
n/an/a 1.5n/an/an/an/an/an/a



Wyeth Research



Assay Description
As a buffer used for the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH7.4), 200 mM Sucrose, and 20 mM MgCl2, 0.125% Bovin Serum Albumin (BSA) were...

Bioorg Med Chem Lett 19: 3485-8 (2009)


BindingDB Entry DOI: 10.7270/Q28S4S76
More data for this
Ligand-Target Pair