BDBM396208 6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-6-ylmethyl)-2-(3-methyl-oxetan-3-ylmethoxy)-nicotinonitrile::US10308667, Example 111

SMILES: Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC2(C)COC2)n1

InChI Key: InChIKey=QNLOMDBXQLKWNA-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 396208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin O-acyltransferase (Homo sapiens (Human))	BDBM396208 (6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...) Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(OCC2(C)COC2)n1 Show InChI InChI=1S/C18H18N6O3/c1-10-13(14(20)15-16(21-10)24-27-23-15)5-12-4-3-11(6-19)17(22-12)26-9-18(2)7-25-8-18/h3-4H,5,7-9,20H2,1-2H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...				Bioorg Med Chem Lett 17: 4664-9 (2007) BindingDB Entry DOI: 10.7270/Q2VH5R5S
					More data for this Ligand-Target Pair