BDBM396229 6-[5-Bromo-6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-2-ylmethyl]-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridin-7-ylamine::US10308667, Example 132

SMILES: Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CCC(F)(F)C1

InChI Key: InChIKey=BQUQJPFUSLRUPE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 396229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin O-acyltransferase (Homo sapiens (Human))	BDBM396229 (6-[5-Bromo-6-(3,3-difluoro-pyrrolidin-1-yl)-pyridi...) Show SMILES Cc1nc2nonc2c(N)c1Cc1ccc(Br)c(n1)N1CCC(F)(F)C1 Show InChI InChI=1S/C16H15BrF2N6O/c1-8-10(12(20)13-14(21-8)24-26-23-13)6-9-2-3-11(17)15(22-9)25-5-4-16(18,19)7-25/h2-3H,4-7,20H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...				Bioorg Med Chem Lett 17: 4664-9 (2007) BindingDB Entry DOI: 10.7270/Q2VH5R5S
					More data for this Ligand-Target Pair