BDBM396687 6-(6'-methoxy-[2,2'-bipyridin]-3- yl)imidazo[1,2-a]pyridine-3-carboxamide::US9981944, Example 33
SMILES: COc1cccc(n1)-c1ncccc1-c1ccc2ncc(C(N)=O)n2c1
InChI Key: InChIKey=LBHOAKVBSFBSEX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type II (Homo sapiens (Human)) | BDBM396687 (6-(6'-methoxy-[2,2'-bipyridin]-3- yl)imidazo[1,2-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ... | Bioorg Med Chem Lett 19: 451-8 (2009) BindingDB Entry DOI: 10.7270/Q2Z89FQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-betaR1 T204D (Homo sapiens (Human)) | BDBM396687 (6-(6'-methoxy-[2,2'-bipyridin]-3- yl)imidazo[1,2-a...) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Anadys Pharmaceuticals | Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ... | Bioorg Med Chem Lett 19: 451-8 (2009) BindingDB Entry DOI: 10.7270/Q2Z89FQ8 | |||||||||||
More data for this Ligand-Target Pair |