BDBM396701 6-(6'-chloro-[2,2'-bipyridin]-3- yl)imidazo[1,2-a]pyridine-3-carboxamide::US9981944, Example 46

SMILES: NC(=O)c1cnc2ccc(cn12)-c1cccnc1-c1cccc(Cl)n1

InChI Key: InChIKey=HNHOOWUAJZGFKM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 396701   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type II (Homo sapiens (Human))	BDBM396701 (6-(6'-chloro-[2,2'-bipyridin]-3- yl)imidazo[1,2-a]...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1cccnc1-c1cccc(Cl)n1 Show InChI InChI=1S/C18H12ClN5O/c19-15-5-1-4-13(23-15)17-12(3-2-8-21-17)11-6-7-16-22-9-14(18(20)25)24(16)10-11/h1-10H,(H2,20,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...				Bioorg Med Chem Lett 19: 451-8 (2009) BindingDB Entry DOI: 10.7270/Q2Z89FQ8
					More data for this Ligand-Target Pair
TGF-betaR1 T204D (Homo sapiens (Human))	BDBM396701 (6-(6'-chloro-[2,2'-bipyridin]-3- yl)imidazo[1,2-a]...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1cccnc1-c1cccc(Cl)n1 Show InChI InChI=1S/C18H12ClN5O/c19-15-5-1-4-13(23-15)17-12(3-2-8-21-17)11-6-7-16-22-9-14(18(20)25)24(16)10-11/h1-10H,(H2,20,25)	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Anadys Pharmaceuticals					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or ...				Bioorg Med Chem Lett 19: 451-8 (2009) BindingDB Entry DOI: 10.7270/Q2Z89FQ8
					More data for this Ligand-Target Pair