BDBM397113 N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(2-thiazolyl)-3-pyridinecarboxamide::US10456385, Example 3::US9987259, Example 3

SMILES: O=C(N[C@@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1

InChI Key: InChIKey=VQRZHJLNDICSPM-CYBMUJFWSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397113   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM397113 (N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(2-...) Show SMILES O=C(N[C@@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1 |r,wD:3.2,(1.18,1.92,;1.18,.38,;2.52,-.39,;3.85,.38,;3.85,1.93,;5.19,2.7,;6.52,1.93,;6.52,.38,;5.19,-.39,;5.9,.96,;4.42,1.36,;-.15,-.39,;-.15,-1.93,;-1.48,-2.7,;-2.82,-1.93,;-4.15,-2.7,;-2.82,-.39,;-1.48,.38,;-4.15,.38,;-4.15,1.92,;-5.61,2.4,;-6.52,1.15,;-5.61,-.09,)| Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
SK BIOPHARMACEUTICALS CO., LTD. US Patent					Assay Description Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...				US Patent US10456385 (2019) BindingDB Entry DOI: 10.7270/Q2V12762
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM397113 (N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-(2-...) Show SMILES O=C(N[C@@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1 |r,wD:3.2,(1.18,1.92,;1.18,.38,;2.52,-.39,;3.85,.38,;3.85,1.93,;5.19,2.7,;6.52,1.93,;6.52,.38,;5.19,-.39,;5.9,.96,;4.42,1.36,;-.15,-.39,;-.15,-1.93,;-1.48,-2.7,;-2.82,-1.93,;-4.15,-2.7,;-2.82,-.39,;-1.48,.38,;-4.15,.38,;-4.15,1.92,;-5.61,2.4,;-6.52,1.15,;-5.61,-.09,)| Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)/t13-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Yale University					Assay Description On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...				Bioorg Med Chem 17: 1764-71 (2009) BindingDB Entry DOI: 10.7270/Q2X92DNB
					More data for this Ligand-Target Pair