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SMILES: O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCC1

InChI Key: InChIKey=IXCQVALROROVHB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397130   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM397130 (N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-cyclopentyl...) Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCC1 |(3.14,1.92,;3.14,.38,;4.47,-.39,;5.81,.38,;5.81,1.93,;7.14,2.7,;8.47,1.93,;8.47,.38,;7.14,-.39,;7.86,.96,;6.37,1.36,;1.81,-.39,;1.81,-1.93,;.47,-2.7,;-.86,-1.93,;-2.19,-2.7,;-.86,-.39,;.47,.38,;-2.19,.38,;-2.19,1.92,;-3.66,2.4,;-4.56,1.15,;-3.66,-.09,;-6.1,1.15,;-7.01,2.4,;-8.47,1.92,;-8.47,.38,;-7.01,-.09,)| Show InChI InChI=1S/C21H26N4O2S/c26-19-6-5-16(20(27)23-17-13-24-9-7-14(17)8-10-24)12-25(19)21-22-11-18(28-21)15-3-1-2-4-15/h5-6,11-12,14-15,17H,1-4,7-10,13H2,(H,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
SK BIOPHARMACEUTICALS CO., LTD. US Patent					Assay Description Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...				US Patent US10456385 (2019) BindingDB Entry DOI: 10.7270/Q2V12762
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM397130 (N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-cyclopentyl...) Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCC1 |(3.14,1.92,;3.14,.38,;4.47,-.39,;5.81,.38,;5.81,1.93,;7.14,2.7,;8.47,1.93,;8.47,.38,;7.14,-.39,;7.86,.96,;6.37,1.36,;1.81,-.39,;1.81,-1.93,;.47,-2.7,;-.86,-1.93,;-2.19,-2.7,;-.86,-.39,;.47,.38,;-2.19,.38,;-2.19,1.92,;-3.66,2.4,;-4.56,1.15,;-3.66,-.09,;-6.1,1.15,;-7.01,2.4,;-8.47,1.92,;-8.47,.38,;-7.01,-.09,)| Show InChI InChI=1S/C21H26N4O2S/c26-19-6-5-16(20(27)23-17-13-24-9-7-14(17)8-10-24)12-25(19)21-22-11-18(28-21)15-3-1-2-4-15/h5-6,11-12,14-15,17H,1-4,7-10,13H2,(H,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Yale University					Assay Description On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...				Bioorg Med Chem 17: 1764-71 (2009) BindingDB Entry DOI: 10.7270/Q2X92DNB
					More data for this Ligand-Target Pair