BDBM397136 N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[5-(phenylmethyl)-2-thiazolyl)]-3-pyridine carboxamide::US10456385, Example 29::US9987259, Example 29

SMILES: O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(Cc2ccccc2)s1

InChI Key: InChIKey=KGZOLQLWJGJBCT-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 397136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM397136 (N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[5-(phen...) Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(Cc2ccccc2)s1 |(3.49,.69,;3.49,-.85,;4.83,-1.62,;6.16,-.85,;6.16,.69,;7.5,1.46,;8.83,.69,;8.83,-.85,;7.5,-1.62,;8.21,-.27,;6.73,.13,;2.16,-1.62,;2.16,-3.16,;.83,-3.93,;-.51,-3.16,;-1.84,-3.93,;-.51,-1.62,;.83,-.85,;-1.84,-.85,;-1.84,.69,;-3.3,1.17,;-4.21,-.08,;-5.75,-.08,;-6.52,1.26,;-5.75,2.59,;-6.52,3.93,;-8.06,3.93,;-8.83,2.59,;-8.06,1.26,;-3.3,-1.32,)| Show InChI InChI=1S/C23H24N4O2S/c28-21-7-6-18(22(29)25-20-15-26-10-8-17(20)9-11-26)14-27(21)23-24-13-19(30-23)12-16-4-2-1-3-5-16/h1-7,13-14,17,20H,8-12,15H2,(H,25,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
SK BIOPHARMACEUTICALS CO., LTD. US Patent					Assay Description Activity of heteromeric α7 nAChR was measured via FlexStation-Ca2+ influx assay. In the present example, in consideration of α7 nAChR being...				US Patent US10456385 (2019) BindingDB Entry DOI: 10.7270/Q2V12762
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM397136 (N-(1-azabicyclo[2.2.2]octan-3-yl)-6-oxo-1-[5-(phen...) Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(Cc2ccccc2)s1 |(3.49,.69,;3.49,-.85,;4.83,-1.62,;6.16,-.85,;6.16,.69,;7.5,1.46,;8.83,.69,;8.83,-.85,;7.5,-1.62,;8.21,-.27,;6.73,.13,;2.16,-1.62,;2.16,-3.16,;.83,-3.93,;-.51,-3.16,;-1.84,-3.93,;-.51,-1.62,;.83,-.85,;-1.84,-.85,;-1.84,.69,;-3.3,1.17,;-4.21,-.08,;-5.75,-.08,;-6.52,1.26,;-5.75,2.59,;-6.52,3.93,;-8.06,3.93,;-8.83,2.59,;-8.06,1.26,;-3.3,-1.32,)| Show InChI InChI=1S/C23H24N4O2S/c28-21-7-6-18(22(29)25-20-15-26-10-8-17(20)9-11-26)14-27(21)23-24-13-19(30-23)12-16-4-2-1-3-5-16/h1-7,13-14,17,20H,8-12,15H2,(H,25,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Yale University					Assay Description On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...				Bioorg Med Chem 17: 1764-71 (2009) BindingDB Entry DOI: 10.7270/Q2X92DNB
					More data for this Ligand-Target Pair