BDBM3981 1 H-indole-3-alkanamide deriv. 7::Dimethyl 2,2 -Dithiobis(1H-indole-3-propanoate)::dithiobis(1H-indole-3-alkanoic acid) deriv. 29::methyl 3-(2-{[3-(3-methoxy-3-oxopropyl)-1H-indol-2-yl]disulfanyl}-1H-indol-3-yl)propanoate
SMILES: COC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)OC)[nH]c2ccccc12
InChI Key: InChIKey=ZMWAFESFFVDUCV-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3981 (1 H-indole-3-alkanamide deriv. 7 | Dimethyl 2,2 -D...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 36: 2459-69 (1993) Article DOI: 10.1021/jm00069a003 BindingDB Entry DOI: 10.7270/Q2RJ4GNS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase transforming protein Src (Avian sarcoma virus) | BDBM3981 (1 H-indole-3-alkanamide deriv. 7 | Dimethyl 2,2 -D...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 37: 598-609 (1994) Article DOI: 10.1021/jm00031a009 BindingDB Entry DOI: 10.7270/Q2MS3QZH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM3981 (1 H-indole-3-alkanamide deriv. 7 | Dimethyl 2,2 -D...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of Auckland | Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe... | J Med Chem 37: 598-609 (1994) Article DOI: 10.1021/jm00031a009 BindingDB Entry DOI: 10.7270/Q2MS3QZH | |||||||||||
More data for this Ligand-Target Pair |