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SMILES: CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccc(F)cc1

InChI Key: InChIKey=KIQMSYZMENVHFU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398401   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398401
PNG
(US10323018, Compound I-130)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCc1ccn2ncnc2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FN5O2/c1-2-33-23-13-21(17-3-6-19(26)7-4-17)30-22-12-18(5-8-20(22)23)25(32)27-14-16-9-10-31-24(11-16)28-15-29-31/h3-13,15H,2,14H2,1H3,(H,27,32)
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n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair