BindingDB logo
myBDB logout

null

SMILES: CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1nnc[nH]1)-c1cc(OC)ncc1Cl

InChI Key: InChIKey=GHJKQQDFTZJUDZ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 398435   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM398435
PNG
(US10323018, Compound I-164)
Show SMILES CCOc1cc(nc2cc(ccc12)C(=O)NCCCc1nnc[nH]1)-c1cc(OC)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O3/c1-3-33-20-11-19(16-10-22(32-2)26-12-17(16)24)29-18-9-14(6-7-15(18)20)23(31)25-8-4-5-21-27-13-28-30-21/h6-7,9-13H,3-5,8H2,1-2H3,(H,25,31)(H,27,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Wyeth Research



Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

Bioorg Med Chem Lett 19: 5225-8 (2009)


BindingDB Entry DOI: 10.7270/Q2Z60RF9
More data for this
Ligand-Target Pair