null
SMILES: COc1c(F)cccc1Nc1cc(Nc2ccc(cn2)N2CCOCC2)nc2[nH]n(C)c(=O)c12
InChI Key: InChIKey=CCYBYUPVDILFCX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Non-receptor tyrosine-protein kinase TYK2 [V731I] (Homo sapiens (Human)) | BDBM399645 (US10323036, Compound I-89 | US10793574, Compound I...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a |
Novartis Institute for Tropical Diseases | Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di... | Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human)) | BDBM399645 (US10323036, Compound I-89 | US10793574, Compound I...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c... | Citation and Details BindingDB Entry DOI: 10.7270/Q2P27291 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human)) | BDBM399645 (US10323036, Compound I-89 | US10793574, Compound I...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a |
Nimbus Lakshmi, Inc. US Patent | Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di... | US Patent US10793574 (2020) BindingDB Entry DOI: 10.7270/Q2WM1HH6 | |||||||||||
More data for this Ligand-Target Pair |