null

SMILES: Cn1[nH]c2nc(Nc3ccccn3)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O

InChI Key: InChIKey=WTPGRZWNZVYEPJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 399698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 [V731] (Homo sapiens (Human))	BDBM399698 (US10323036, Compound I-142 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3ccccn3)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C19H18N6O3S/c1-25-19(26)17-13(21-12-7-3-4-8-14(12)29(2,27)28)11-16(23-18(17)24-25)22-15-9-5-6-10-20-15/h3-11H,1-2H3,(H3,20,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				Anal Biochem 395: 195-204 (2009) BindingDB Entry DOI: 10.7270/Q2X63Q9X
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399698 (US10323036, Compound I-142 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3ccccn3)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C19H18N6O3S/c1-25-19(26)17-13(21-12-7-3-4-8-14(12)29(2,27)28)11-16(23-18(17)24-25)22-15-9-5-6-10-20-15/h3-11H,1-2H3,(H3,20,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [556-888] (Homo sapiens (Human))	BDBM399698 (US10323036, Compound I-142 | US10793574, Compound ...) Show SMILES Cn1[nH]c2nc(Nc3ccccn3)cc(Nc3ccccc3S(C)(=O)=O)c2c1=O Show InChI InChI=1S/C19H18N6O3S/c1-25-19(26)17-13(21-12-7-3-4-8-14(12)29(2,27)28)11-16(23-18(17)24-25)22-15-9-5-6-10-20-15/h3-11H,1-2H3,(H3,20,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...				US Patent US10793574 (2020)
					More data for this Ligand-Target Pair