BDBM4063 8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::8-methyl-6-phenyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one deriv. 24

SMILES: Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O

InChI Key: InChIKey=ZKZKULAYQWBXQM-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 6 PDB IDs contain this monomer as substructures. 6 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4063 (8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]py...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O Show InChI InChI=1S/C20H16N4O/c1-24-18-15(12-17(19(24)25)14-8-4-2-5-9-14)13-21-20(23-18)22-16-10-6-3-7-11-16/h2-13H,1H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4063 (8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]py...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O Show InChI InChI=1S/C20H16N4O/c1-24-18-15(12-17(19(24)25)14-8-4-2-5-9-14)13-21-20(23-18)22-16-10-6-3-7-11-16/h2-13H,1H3,(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4063 (8-Methyl-6-phenyl-2-phenylamino-8H-pyrido[2,3-d]py...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2ccccc2)c1=O Show InChI InChI=1S/C20H16N4O/c1-24-18-15(12-17(19(24)25)14-8-4-2-5-9-14)13-21-20(23-18)22-16-10-6-3-7-11-16/h2-13H,1H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Parke-Davis Pharmaceutical Research					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 41: 4365-77 (1998) Article DOI: 10.1021/jm980398y BindingDB Entry DOI: 10.7270/Q2CC0XWN
					More data for this Ligand-Target Pair