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SMILES: Cc1ccnc(c1)-c1nc(Nc2ccncc2F)c2cccn2n1

InChI Key: InChIKey=FNHAFWZMKCOICG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406779   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-2 (Homo sapiens (Human))	BDBM406779 (3-fluoro-N-[2-(4-methylpyridin-2-yl)pyrrolo[2,1-f]...) Show SMILES Cc1ccnc(c1)-c1nc(Nc2ccncc2F)c2cccn2n1 Show InChI InChI=1S/C17H13FN6/c1-11-4-7-20-14(9-11)16-22-17(15-3-2-8-24(15)23-16)21-13-5-6-19-10-12(13)18/h2-10H,1H3,(H,19,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406779 (3-fluoro-N-[2-(4-methylpyridin-2-yl)pyrrolo[2,1-f]...) Show SMILES Cc1ccnc(c1)-c1nc(Nc2ccncc2F)c2cccn2n1 Show InChI InChI=1S/C17H13FN6/c1-11-4-7-20-14(9-11)16-22-17(15-3-2-8-24(15)23-16)21-13-5-6-19-10-12(13)18/h2-10H,1H3,(H,19,21,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair