null

SMILES: CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnn(CC(F)(F)F)c1)-c1ccc2cc(cnn12)C#N

InChI Key: InChIKey=GIKOKFUAVKJQBE-OAQYLSRUSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407110   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM407110 ((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnn(CC(F)(F)F)c1)-c1ccc2cc(cnn12)C#N |r| Show InChI InChI=1S/C24H22F4N8O2/c1-23(2,38)21(25)11-31-22(37)17-10-30-19(20-4-3-16-5-14(7-29)8-33-36(16)20)6-18(17)34-15-9-32-35(12-15)13-24(26,27)28/h3-6,8-10,12,21,38H,11,13H2,1-2H3,(H,30,34)(H,31,37)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco® 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...				US Patent US10336762 (2019) BindingDB Entry DOI: 10.7270/Q2GH9MBG
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM407110 ((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnn(CC(F)(F)F)c1)-c1ccc2cc(cnn12)C#N |r| Show InChI InChI=1S/C24H22F4N8O2/c1-23(2,38)21(25)11-31-22(37)17-10-30-19(20-4-3-16-5-14(7-29)8-33-36(16)20)6-18(17)34-15-9-32-35(12-15)13-24(26,27)28/h3-6,8-10,12,21,38H,11,13H2,1-2H3,(H,30,34)(H,31,37)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco® 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...				US Patent US10336762 (2019) BindingDB Entry DOI: 10.7270/Q2GH9MBG
					More data for this Ligand-Target Pair