Found 6 hits for monomerid = 407814 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tumor necrosis factor
(Homo sapiens (Human)) | BDBM407814
((R)-methyl ((3-((2-(3- cyanopyrrolo[1,2- b]pyridaz...)Show SMILES COC(=O)NCC1(F)CC(C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:22.24,(9.53,3.78,;8.19,3.01,;6.86,3.78,;6.86,5.32,;5.52,3.01,;4.19,3.78,;2.86,3.01,;2.46,4.5,;2.46,1.52,;.97,1.92,;1.37,3.41,;-.36,1.15,;-.36,-.39,;.97,-1.16,;.97,-2.7,;-.36,-3.47,;-1.7,-2.7,;-1.7,-1.16,;-3.03,-.39,;-3.03,1.15,;-4.36,-1.16,;-5.7,-.39,;-7.03,-1.16,;-7.03,-2.7,;-8.37,-.39,;-9.7,-1.16,;-8.37,1.15,;-9.7,.38,;2.3,-3.47,;2.47,-5,;3.97,-5.32,;4.74,-3.99,;6.25,-3.67,;6.72,-2.2,;5.69,-1.06,;4.19,-1.38,;3.71,-2.84,;8.21,-1.8,;9.7,-1.4,)| Show InChI InChI=1S/C26H29F2N7O4/c1-25(2,38)22(27)13-31-23(36)18-12-30-20(21-5-4-17-6-15(10-29)11-33-35(17)21)7-19(18)34-16-8-26(28,9-16)14-32-24(37)39-3/h4-7,11-12,16,22,38H,8-9,13-14H2,1-3H3,(H,30,34)(H,31,36)(H,32,37)/t16?,22-,26?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
US Patent
| Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ... |
US Patent US10336762 (2019)
BindingDB Entry DOI: 10.7270/Q2GH9MBG |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM407814
((R)-methyl ((3-((2-(3- cyanopyrrolo[1,2- b]pyridaz...)Show SMILES COC(=O)NCC1(F)CC(C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:22.24,(9.53,3.78,;8.19,3.01,;6.86,3.78,;6.86,5.32,;5.52,3.01,;4.19,3.78,;2.86,3.01,;2.46,4.5,;2.46,1.52,;.97,1.92,;1.37,3.41,;-.36,1.15,;-.36,-.39,;.97,-1.16,;.97,-2.7,;-.36,-3.47,;-1.7,-2.7,;-1.7,-1.16,;-3.03,-.39,;-3.03,1.15,;-4.36,-1.16,;-5.7,-.39,;-7.03,-1.16,;-7.03,-2.7,;-8.37,-.39,;-9.7,-1.16,;-8.37,1.15,;-9.7,.38,;2.3,-3.47,;2.47,-5,;3.97,-5.32,;4.74,-3.99,;6.25,-3.67,;6.72,-2.2,;5.69,-1.06,;4.19,-1.38,;3.71,-2.84,;8.21,-1.8,;9.7,-1.4,)| Show InChI InChI=1S/C26H29F2N7O4/c1-25(2,38)22(27)13-31-23(36)18-12-30-20(21-5-4-17-6-15(10-29)11-33-35(17)21)7-19(18)34-16-8-26(28,9-16)14-32-24(37)39-3/h4-7,11-12,16,22,38H,8-9,13-14H2,1-3H3,(H,30,34)(H,31,36)(H,32,37)/t16?,22-,26?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
US Patent
| Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ... |
US Patent US10336762 (2019)
BindingDB Entry DOI: 10.7270/Q2GH9MBG |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM407814
((R)-methyl ((3-((2-(3- cyanopyrrolo[1,2- b]pyridaz...)Show SMILES COC(=O)NCC1(F)CC(C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:22.24,(9.53,3.78,;8.19,3.01,;6.86,3.78,;6.86,5.32,;5.52,3.01,;4.19,3.78,;2.86,3.01,;2.46,4.5,;2.46,1.52,;.97,1.92,;1.37,3.41,;-.36,1.15,;-.36,-.39,;.97,-1.16,;.97,-2.7,;-.36,-3.47,;-1.7,-2.7,;-1.7,-1.16,;-3.03,-.39,;-3.03,1.15,;-4.36,-1.16,;-5.7,-.39,;-7.03,-1.16,;-7.03,-2.7,;-8.37,-.39,;-9.7,-1.16,;-8.37,1.15,;-9.7,.38,;2.3,-3.47,;2.47,-5,;3.97,-5.32,;4.74,-3.99,;6.25,-3.67,;6.72,-2.2,;5.69,-1.06,;4.19,-1.38,;3.71,-2.84,;8.21,-1.8,;9.7,-1.4,)| Show InChI InChI=1S/C26H29F2N7O4/c1-25(2,38)22(27)13-31-23(36)18-12-30-20(21-5-4-17-6-15(10-29)11-33-35(17)21)7-19(18)34-16-8-26(28,9-16)14-32-24(37)39-3/h4-7,11-12,16,22,38H,8-9,13-14H2,1-3H3,(H,30,34)(H,31,36)(H,32,37)/t16?,22-,26?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
US Patent
| Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ... |
US Patent US10336762 (2019)
BindingDB Entry DOI: 10.7270/Q2GH9MBG |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM407814
((R)-methyl ((3-((2-(3- cyanopyrrolo[1,2- b]pyridaz...)Show SMILES COC(=O)NCC1(F)CC(C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:22.24,(9.53,3.78,;8.19,3.01,;6.86,3.78,;6.86,5.32,;5.52,3.01,;4.19,3.78,;2.86,3.01,;2.46,4.5,;2.46,1.52,;.97,1.92,;1.37,3.41,;-.36,1.15,;-.36,-.39,;.97,-1.16,;.97,-2.7,;-.36,-3.47,;-1.7,-2.7,;-1.7,-1.16,;-3.03,-.39,;-3.03,1.15,;-4.36,-1.16,;-5.7,-.39,;-7.03,-1.16,;-7.03,-2.7,;-8.37,-.39,;-9.7,-1.16,;-8.37,1.15,;-9.7,.38,;2.3,-3.47,;2.47,-5,;3.97,-5.32,;4.74,-3.99,;6.25,-3.67,;6.72,-2.2,;5.69,-1.06,;4.19,-1.38,;3.71,-2.84,;8.21,-1.8,;9.7,-1.4,)| Show InChI InChI=1S/C26H29F2N7O4/c1-25(2,38)22(27)13-31-23(36)18-12-30-20(21-5-4-17-6-15(10-29)11-33-35(17)21)7-19(18)34-16-8-26(28,9-16)14-32-24(37)39-3/h4-7,11-12,16,22,38H,8-9,13-14H2,1-3H3,(H,30,34)(H,31,36)(H,32,37)/t16?,22-,26?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
US Patent
| Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ... |
US Patent US10336762 (2019)
BindingDB Entry DOI: 10.7270/Q2GH9MBG |
More data for this Ligand-Target Pair | |
Tumor necrosis factor
(Homo sapiens (Human)) | BDBM407814
((R)-methyl ((3-((2-(3- cyanopyrrolo[1,2- b]pyridaz...)Show SMILES COC(=O)NCC1(F)CC(C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:22.24,(9.53,3.78,;8.19,3.01,;6.86,3.78,;6.86,5.32,;5.52,3.01,;4.19,3.78,;2.86,3.01,;2.46,4.5,;2.46,1.52,;.97,1.92,;1.37,3.41,;-.36,1.15,;-.36,-.39,;.97,-1.16,;.97,-2.7,;-.36,-3.47,;-1.7,-2.7,;-1.7,-1.16,;-3.03,-.39,;-3.03,1.15,;-4.36,-1.16,;-5.7,-.39,;-7.03,-1.16,;-7.03,-2.7,;-8.37,-.39,;-9.7,-1.16,;-8.37,1.15,;-9.7,.38,;2.3,-3.47,;2.47,-5,;3.97,-5.32,;4.74,-3.99,;6.25,-3.67,;6.72,-2.2,;5.69,-1.06,;4.19,-1.38,;3.71,-2.84,;8.21,-1.8,;9.7,-1.4,)| Show InChI InChI=1S/C26H29F2N7O4/c1-25(2,38)22(27)13-31-23(36)18-12-30-20(21-5-4-17-6-15(10-29)11-33-35(17)21)7-19(18)34-16-8-26(28,9-16)14-32-24(37)39-3/h4-7,11-12,16,22,38H,8-9,13-14H2,1-3H3,(H,30,34)(H,31,36)(H,32,37)/t16?,22-,26?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 323 | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
US Patent
| Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ... |
US Patent US10336762 (2019)
BindingDB Entry DOI: 10.7270/Q2GH9MBG |
More data for this Ligand-Target Pair | |
Tumor necrosis factor
(Homo sapiens (Human)) | BDBM407814
((R)-methyl ((3-((2-(3- cyanopyrrolo[1,2- b]pyridaz...)Show SMILES COC(=O)NCC1(F)CC(C1)Nc1cc(ncc1C(=O)NC[C@@H](F)C(C)(C)O)-c1ccc2cc(cnn12)C#N |r,wU:22.24,(9.53,3.78,;8.19,3.01,;6.86,3.78,;6.86,5.32,;5.52,3.01,;4.19,3.78,;2.86,3.01,;2.46,4.5,;2.46,1.52,;.97,1.92,;1.37,3.41,;-.36,1.15,;-.36,-.39,;.97,-1.16,;.97,-2.7,;-.36,-3.47,;-1.7,-2.7,;-1.7,-1.16,;-3.03,-.39,;-3.03,1.15,;-4.36,-1.16,;-5.7,-.39,;-7.03,-1.16,;-7.03,-2.7,;-8.37,-.39,;-9.7,-1.16,;-8.37,1.15,;-9.7,.38,;2.3,-3.47,;2.47,-5,;3.97,-5.32,;4.74,-3.99,;6.25,-3.67,;6.72,-2.2,;5.69,-1.06,;4.19,-1.38,;3.71,-2.84,;8.21,-1.8,;9.7,-1.4,)| Show InChI InChI=1S/C26H29F2N7O4/c1-25(2,38)22(27)13-31-23(36)18-12-30-20(21-5-4-17-6-15(10-29)11-33-35(17)21)7-19(18)34-16-8-26(28,9-16)14-32-24(37)39-3/h4-7,11-12,16,22,38H,8-9,13-14H2,1-3H3,(H,30,34)(H,31,36)(H,32,37)/t16?,22-,26?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
US Patent
| Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ... |
US Patent US10336762 (2019)
BindingDB Entry DOI: 10.7270/Q2GH9MBG |
More data for this Ligand-Target Pair | |