null

SMILES: CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnc(nc1)N1CC2CC(C1)O2)-c1ccc2cc(cnn12)C#N

InChI Key: InChIKey=MTJBTELDNSRLHX-OZTQUORISA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407975   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM407975 (4-((2-(6-oxa-3-aza- bicyclo[3.1.1]heptan-3-yl) pyr...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnc(nc1)N1CC2CC(C1)O2)-c1ccc2cc(cnn12)C#N |r| Show InChI InChI=1S/C28H28FN9O3/c1-28(2,40)25(29)13-32-26(39)21-12-31-23(24-4-3-18-5-16(8-30)9-35-38(18)24)7-22(21)36-17-10-33-27(34-11-17)37-14-19-6-20(15-37)41-19/h3-5,7,9-12,19-20,25,40H,6,13-15H2,1-2H3,(H,31,36)(H,32,39)/t19?,20?,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco® 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...				US Patent US10336762 (2019) BindingDB Entry DOI: 10.7270/Q2GH9MBG
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM407975 (4-((2-(6-oxa-3-aza- bicyclo[3.1.1]heptan-3-yl) pyr...) Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1Nc1cnc(nc1)N1CC2CC(C1)O2)-c1ccc2cc(cnn12)C#N |r| Show InChI InChI=1S/C28H28FN9O3/c1-28(2,40)25(29)13-32-26(39)21-12-31-23(24-4-3-18-5-16(8-30)9-35-38(18)24)7-22(21)36-17-10-33-27(34-11-17)37-14-19-6-20(15-37)41-19/h3-5,7,9-12,19-20,25,40H,6,13-15H2,1-2H3,(H,31,36)(H,32,39)/t19?,20?,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco® 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...				US Patent US10336762 (2019) BindingDB Entry DOI: 10.7270/Q2GH9MBG
					More data for this Ligand-Target Pair