null
SMILES: CNS(=O)(=O)C[C@H]1CCC(CC1)N(C)c1cc(Cl)nc(N)n1
InChI Key: InChIKey=YSFPFEAQYFWCQC-OKXAEBFBSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 [866-1154] (Homo sapiens (Human)) | BDBM410162 (US10370375, Example 10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elanco Tiergesundheit AG US Patent | Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8... | US Patent US10370375 (2019) BindingDB Entry DOI: 10.7270/Q2ZC857B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Homo sapiens (Human)) | BDBM410162 (US10370375, Example 10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elanco Tiergesundheit AG US Patent | Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8... | US Patent US10370375 (2019) BindingDB Entry DOI: 10.7270/Q2ZC857B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 [811-1124] (Homo sapiens (Human)) | BDBM410162 (US10370375, Example 10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Elanco Tiergesundheit AG US Patent | Assay Description All four kinases of the JAK/TYK-kinase family were used as purified recombinant GST-fusion proteins, containing the active kinase domains. GST-JAK1(8... | US Patent US10370375 (2019) BindingDB Entry DOI: 10.7270/Q2ZC857B | |||||||||||
More data for this Ligand-Target Pair |