null
SMILES: CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(NC(=O)C2(C)CN(C(=O)CN3C[C@@H](C)NC[C@@H]3CN3CCOC[C@H]3C)c3cc(Cc4ccc(F)cc4)ccc23)cc1
InChI Key: InChIKey=CVZJCEWUSZWWLC-IKPIZQADSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase XIAP [124-240] (Homo sapiens (Human)) | BDBM412177 (N-(4-(4-fluoro-3-((S)-2-((S)- 2-((S)-2- (methylami...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For the Bir2 assay, 3.5 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine disclosed as SEQ ID NO: 25), corresponding to amino acids 124-240 ... | US Patent US10398702 (2019) BindingDB Entry DOI: 10.7270/Q2VH5R67 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 [260-351] (Homo sapiens (Human)) | BDBM412177 (N-(4-(4-fluoro-3-((S)-2-((S)- 2-((S)-2- (methylami...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For the Bir3 assay, 25.5 nanomolar BIR3 domain, corresponding to amino acids 260-352 of cIAP, was mixed with 41 nM of the peptide AVPIAQKSEK-(ε-... | US Patent US10398702 (2019) BindingDB Entry DOI: 10.7270/Q2VH5R67 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 [174-256] (Homo sapiens (Human)) | BDBM412177 (N-(4-(4-fluoro-3-((S)-2-((S)- 2-((S)-2- (methylami...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 327 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For the Bir2 assay, 12 nanomolar of 6× Histidine-tagged BIR2 domain (6× Histidine38 disclosed as SEQ ID NO: 25), corresponding to amino acids 174-256... | US Patent US10398702 (2019) BindingDB Entry DOI: 10.7270/Q2VH5R67 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase XIAP [241-356] (Homo sapiens (Human)) | BDBM412177 (N-(4-(4-fluoro-3-((S)-2-((S)- 2-((S)-2- (methylami...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For the Bir3 assay, 13.3 nanomolar BIR3 domain, corresponding to amino acids 241-356 of XIAP, was mixed with 25.2 nM of the peptide AVPIAQKSEK-(ε... | US Patent US10398702 (2019) BindingDB Entry DOI: 10.7270/Q2VH5R67 | |||||||||||
More data for this Ligand-Target Pair |