null

SMILES: Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1

InChI Key: InChIKey=HWVQNXSYFNWAIF-LEAFIULHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 412325   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM412325 (US10399945, Example 54 | US10927079, Compound 54) Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1 |r| Show InChI InChI=1S/C32H33F2N5O3/c1-17-11-24(37-30(41)39-28-20-12-22(33)23(34)13-21(20)31(2,3)14-25(28)40)27(18-9-7-6-8-10-18)38-26(17)19-15-35-29(36-16-19)32(4,5)42/h6-13,15-16,25,28,40,42H,14H2,1-5H3,(H2,37,39,41)/t25-,28-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
MOCHIDA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...				US Patent US10927079 (2021)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM412325 (US10399945, Example 54 | US10927079, Compound 54) Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1 |r| Show InChI InChI=1S/C32H33F2N5O3/c1-17-11-24(37-30(41)39-28-20-12-22(33)23(34)13-21(20)31(2,3)14-25(28)40)27(18-9-7-6-8-10-18)38-26(17)19-15-35-29(36-16-19)32(4,5)42/h6-13,15-16,25,28,40,42H,14H2,1-5H3,(H2,37,39,41)/t25-,28-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
MOCHIDA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...				US Patent US10399945 (2019) BindingDB Entry DOI: 10.7270/Q2BG2RCB
					More data for this Ligand-Target Pair