null

SMILES: COc1cn([C@@H](CC(F)F)C(=O)Nc2ccc3nccnc3c2)c(=O)cc1-c1cc(Cl)ccc1-n1cc(Cl)nn1

InChI Key: InChIKey=SATGRGDFTKEDOC-NRFANRHFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 413864   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor XI (Homo sapiens (Human))	BDBM413864 ((2S)-2-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1...) Show SMILES COc1cn([C@@H](CC(F)F)C(=O)Nc2ccc3nccnc3c2)c(=O)cc1-c1cc(Cl)ccc1-n1cc(Cl)nn1 |r| Show InChI InChI=1S/C26H19Cl2F2N7O3/c1-40-22-12-36(21(11-24(29)30)26(39)33-15-3-4-18-19(9-15)32-7-6-31-18)25(38)10-17(22)16-8-14(27)2-5-20(16)37-13-23(28)34-35-37/h2-10,12-13,21,24H,11H2,1H3,(H,33,39)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...				US Patent US10421742 (2019) BindingDB Entry DOI: 10.7270/Q26M3967
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM413864 ((2S)-2-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1...) Show SMILES COc1cn([C@@H](CC(F)F)C(=O)Nc2ccc3nccnc3c2)c(=O)cc1-c1cc(Cl)ccc1-n1cc(Cl)nn1 |r| Show InChI InChI=1S/C26H19Cl2F2N7O3/c1-40-22-12-36(21(11-24(29)30)26(39)33-15-3-4-18-19(9-15)32-7-6-31-18)25(38)10-17(22)16-8-14(27)2-5-20(16)37-13-23(28)34-35-37/h2-10,12-13,21,24H,11H2,1H3,(H,33,39)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM413864 ((2S)-2-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1...) Show SMILES COc1cn([C@@H](CC(F)F)C(=O)Nc2ccc3nccnc3c2)c(=O)cc1-c1cc(Cl)ccc1-n1cc(Cl)nn1 |r| Show InChI InChI=1S/C26H19Cl2F2N7O3/c1-40-22-12-36(21(11-24(29)30)26(39)33-15-3-4-18-19(9-15)32-7-6-31-18)25(38)10-17(22)16-8-14(27)2-5-20(16)37-13-23(28)34-35-37/h2-10,12-13,21,24H,11H2,1H3,(H,33,39)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM413864 ((2S)-2-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1...) Show SMILES COc1cn([C@@H](CC(F)F)C(=O)Nc2ccc3nccnc3c2)c(=O)cc1-c1cc(Cl)ccc1-n1cc(Cl)nn1 |r| Show InChI InChI=1S/C26H19Cl2F2N7O3/c1-40-22-12-36(21(11-24(29)30)26(39)33-15-3-4-18-19(9-15)32-7-6-31-18)25(38)10-17(22)16-8-14(27)2-5-20(16)37-13-23(28)34-35-37/h2-10,12-13,21,24H,11H2,1H3,(H,33,39)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the reac...				US Patent US10421742 (2019) BindingDB Entry DOI: 10.7270/Q26M3967
					More data for this Ligand-Target Pair