BDBM4193 1,6-naphthyridin-2(1H)-one deriv. 8r::3-(2,6-Dichlorophenyl)-7-[[4-[3-(diethylamino)propoxy]phenyl]amino]-1,6-naphthyridin-2(1H)-one::3-(2,6-dichlorophenyl)-7-({4-[3-(diethylamino)propoxy]phenyl}amino)-1,2-dihydro-1,6-naphthyridin-2-one

SMILES: CCN(CC)CCCOc1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)cc1

InChI Key: InChIKey=GVDMYBWNSNCDMN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4193   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM4193 (1,6-naphthyridin-2(1H)-one deriv. 8r | 3-(2,6-Dich...) Show SMILES CCN(CC)CCCOc1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)cc1 |(-18.31,-.65,;-18.31,.89,;-16.98,1.66,;-16.98,3.2,;-15.65,3.97,;-15.65,.89,;-14.31,1.66,;-13.04,.79,;-11.65,1.45,;-10.39,.57,;-10.51,-.96,;-9.24,-1.84,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;-7.73,.36,;-8.99,1.23,)| Show InChI InChI=1S/C27H28Cl2N4O2/c1-3-33(4-2)13-6-14-35-20-11-9-19(10-12-20)31-25-16-24-18(17-30-25)15-21(27(34)32-24)26-22(28)7-5-8-23(26)29/h5,7-12,15-17H,3-4,6,13-14H2,1-2H3,(H,30,31)(H,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM4193 (1,6-naphthyridin-2(1H)-one deriv. 8r | 3-(2,6-Dich...) Show SMILES CCN(CC)CCCOc1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)cc1 |(-18.31,-.65,;-18.31,.89,;-16.98,1.66,;-16.98,3.2,;-15.65,3.97,;-15.65,.89,;-14.31,1.66,;-13.04,.79,;-11.65,1.45,;-10.39,.57,;-10.51,-.96,;-9.24,-1.84,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;-7.73,.36,;-8.99,1.23,)| Show InChI InChI=1S/C27H28Cl2N4O2/c1-3-33(4-2)13-6-14-35-20-11-9-19(10-12-20)31-25-16-24-18(17-30-25)15-21(27(34)32-24)26-22(28)7-5-8-23(26)29/h5,7-12,15-17H,3-4,6,13-14H2,1-2H3,(H,30,31)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4193 (1,6-naphthyridin-2(1H)-one deriv. 8r | 3-(2,6-Dich...) Show SMILES CCN(CC)CCCOc1ccc(Nc2cc3[nH]c(=O)c(cc3cn2)-c2c(Cl)cccc2Cl)cc1 |(-18.31,-.65,;-18.31,.89,;-16.98,1.66,;-16.98,3.2,;-15.65,3.97,;-15.65,.89,;-14.31,1.66,;-13.04,.79,;-11.65,1.45,;-10.39,.57,;-10.51,-.96,;-9.24,-1.84,;-7.85,-1.18,;-6.52,-1.95,;-5.18,-1.18,;-3.85,-1.95,;-2.52,-1.12,;-1.18,-1.89,;.15,-1.12,;1.48,-1.89,;.15,.42,;-1.18,1.19,;-2.52,.42,;-3.85,1.13,;-5.18,.36,;1.48,1.19,;1.48,2.73,;.15,3.5,;2.82,3.5,;4.15,2.73,;4.15,1.19,;2.82,.42,;2.82,-1.12,;-7.73,.36,;-8.99,1.23,)| Show InChI InChI=1S/C27H28Cl2N4O2/c1-3-33(4-2)13-6-14-35-20-11-9-19(10-12-20)31-25-16-24-18(17-30-25)15-21(27(34)32-24)26-22(28)7-5-8-23(26)29/h5,7-12,15-17H,3-4,6,13-14H2,1-2H3,(H,30,31)(H,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 43: 3134-47 (2000) Article DOI: 10.1021/jm000148t BindingDB Entry DOI: 10.7270/Q2028PQ1
					More data for this Ligand-Target Pair