null

SMILES: Fc1cc(ccc1C#N)N1C[C@@H]2C[C@H]1CN2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 419765   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM419765 (US10464919, Example 103) Show SMILES Fc1cc(ccc1C#N)N1C[C@@H]2C[C@H]1CN2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The PARP-1 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of a kit (cat. 80551) p...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Activated CDC42 kinase 1 (Homo sapiens (Human))	BDBM419765 (US10464919, Example 103) Show SMILES Fc1cc(ccc1C#N)N1C[C@@H]2C[C@H]1CN2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TNK1 (Homo sapiens (Human))	BDBM419765 (US10464919, Example 103) Show SMILES Fc1cc(ccc1C#N)N1C[C@@H]2C[C@H]1CN2Cc1ccc2c3NCCCc3c(=O)[nH]c2c1 |r| Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
Je Il Pharmaceutical Co., Ltd. US Patent					Assay Description The tankyrase-1 or tankyrase-2 enzyme inhibitory activities of the compounds of the present invention were assayed in the following manner by use of ...				US Patent US10464919 (2019) BindingDB Entry DOI: 10.7270/Q2736T8M
					More data for this Ligand-Target Pair