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SMILES: COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCN(C)C

InChI Key: InChIKey=XNRHQBBUSRHRFE-ZDUSSCGKSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420196   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420196
PNG
((7S)—N-[2-(Dimethylamino)ethyl]-4-[(6-methoxypyraz...)
Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCN(C)C |r|
Show InChI InChI=1S/C22H26N8O2S/c1-29(2)9-8-23-21(31)13-4-5-14-16(10-13)33-22-18(14)20(24-12-25-22)28-19-15(32-3)11-30-17(27-19)6-7-26-30/h6-7,11-13H,4-5,8-10H2,1-3H3,(H,23,31)(H,24,25,27,28)/t13-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 3n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair