BDBM420197 (7S)—N-(2-Hydroxyethyl)-4-[(6-methoxypyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide::US10487092, Example 83

SMILES: COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCO

InChI Key: InChIKey=JKZHFMYLGLGOLL-NSHDSACASA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420197   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM420197 ((7S)—N-(2-Hydroxyethyl)-4-[(6-methoxypyrazolo[1,5-...) Show SMILES COc1cn2nccc2nc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)NCCO |r| Show InChI InChI=1S/C20H21N7O3S/c1-30-13-9-27-15(4-5-24-27)25-17(13)26-18-16-12-3-2-11(19(29)21-6-7-28)8-14(12)31-20(16)23-10-22-18/h4-5,9-11,28H,2-3,6-8H2,1H3,(H,21,29)(H,22,23,25,26)/t11-/m0/s1	PDB GoogleScholar AffyNet	KEGG UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
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