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SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N

InChI Key: InChIKey=PSGOWTPRKWLTCN-AWEZNQCLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420250   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420250
PNG
(1-((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)a...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)C#N |r|
Show InChI InChI=1S/C23H21N7O2S/c1-32-18-11-30-15(4-5-27-30)7-17(18)28-21-20-16-3-2-14(23(31)29-9-13(8-24)10-29)6-19(16)33-22(20)26-12-25-21/h4-5,7,11-14H,2-3,6,9-10H2,1H3,(H,25,26,28)/t14-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair