BDBM420252 (3-Hydroxy-3-methylazetidin-1-yl)(7S)-4-[(6-methoxypyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-ylmethanone::US10487092, Example 100

SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C)(O)C1

InChI Key: InChIKey=FKAIUMRWXKFQQA-ZDUSSCGKSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM420252 ((3-Hydroxy-3-methylazetidin-1-yl)(7S)-4-[(6-methox...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C)(O)C1 |r| Show InChI InChI=1S/C23H24N6O3S/c1-23(31)10-28(11-23)22(30)13-3-4-15-18(7-13)33-21-19(15)20(24-12-25-21)27-16-8-14-5-6-26-29(14)9-17(16)32-2/h5-6,8-9,12-13,31H,3-4,7,10-11H2,1-2H3,(H,24,25,27)/t13-/m0/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair