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SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)N(C)C

InChI Key: InChIKey=VJQBMDQILRCOLE-AWEZNQCLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420254   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420254
PNG
(US10487092, Example 102 | [3-(Dimethylamino)azetid...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CC(C1)N(C)C |r|
Show InChI InChI=1S/C24H27N7O2S/c1-29(2)16-10-30(11-16)24(32)14-4-5-17-20(8-14)34-23-21(17)22(25-13-26-23)28-18-9-15-6-7-27-31(15)12-19(18)33-3/h6-7,9,12-14,16H,4-5,8,10-11H2,1-3H3,(H,25,26,28)/t14-/m0/s1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 2n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair