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SMILES: COCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21

InChI Key: InChIKey=PYGNEARBCARCRB-AWEZNQCLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420256   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))		BDBM420256
PNG
((7S)—N-(2-Methoxyethyl)-4-[(6-methoxypyrazolo[1,5-...)
Show SMILES COCCN(C)C(=O)[C@H]1CCc2c(C1)sc1ncnc(Nc3cc4ccnn4cc3OC)c21 |r|
Show InChI InChI=1S/C23H26N6O3S/c1-28(8-9-31-2)23(30)14-4-5-16-19(10-14)33-22-20(16)21(24-13-25-22)27-17-11-15-6-7-26-29(15)12-18(17)32-3/h6-7,11-14H,4-5,8-10H2,1-3H3,(H,24,25,27)/t14-/m0/s1
PDB

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US Patent
n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...

US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair