BDBM420260 US10487092, Example 108::[(3S,4S)-3,4-Dihydroxypyrrolidin-1-yl](7S)-4-[(6-methoxypyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-ylmethanone

SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](O)[C@@H](O)C1

InChI Key: InChIKey=KYXWFSTVEZAOSK-ZLIFDBKOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420260   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM420260 (US10487092, Example 108 | [(3S,4S)-3,4-Dihydroxypy...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H](O)[C@@H](O)C1 |r| Show InChI InChI=1S/C23H24N6O4S/c1-33-18-10-29-13(4-5-26-29)7-15(18)27-21-20-14-3-2-12(6-19(14)34-22(20)25-11-24-21)23(32)28-8-16(30)17(31)9-28/h4-5,7,10-12,16-17,30-31H,2-3,6,8-9H2,1H3,(H,24,25,27)/t12-,16-,17-/m0/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair