BDBM420268 (7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl(morpholin-4-yl)methanone::US10487092, Example 116

SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1

InChI Key: InChIKey=QMPLQZWNIXAOIC-AWEZNQCLSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM420268 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H24N6O3S/c1-31-18-12-29-15(4-5-26-29)11-17(18)27-21-20-16-3-2-14(23(30)28-6-8-32-9-7-28)10-19(16)33-22(20)25-13-24-21/h4-5,11-14H,2-3,6-10H2,1H3,(H,24,25,27)/t14-/m0/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair