BindingDB logo
myBDB logout

null

SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CN2C

InChI Key: InChIKey=HKYAMGNKONTKKL-USXIJHARSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420274   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D]


(Homo sapiens (Human))
BDBM420274
PNG
((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...)
Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@H]2C[C@@H]1CN2C |r,THB:34:33:27.28:30,25:27:32.33:30|
Show InChI InChI=1S/C25H27N7O2S/c1-30-10-17-8-16(30)11-31(17)25(33)14-3-4-18-21(7-14)35-24-22(18)23(26-13-27-24)29-19-9-15-5-6-28-32(15)12-20(19)34-2/h5-6,9,12-14,16-17H,3-4,7-8,10-11H2,1-2H3,(H,26,27,29)/t14-,16+,17+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US10487092 (2019)


BindingDB Entry DOI: 10.7270/Q28W3GPZ
More data for this
Ligand-Target Pair