BDBM420275 (7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-7-yl[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]methanone::US10487092, Example 123

SMILES: COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CO2

InChI Key: InChIKey=HUGQUBQNZPMAHN-BPUTZDHNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 420275   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM420275 ((7S)-4-[(6-Methoxypyrazolo[1,5-a]pyridin-5-yl)amin...) Show SMILES COc1cn2nccc2cc1Nc1ncnc2sc3C[C@H](CCc3c12)C(=O)N1C[C@@H]2C[C@H]1CO2 |r| Show InChI InChI=1S/C24H24N6O3S/c1-32-19-10-30-14(4-5-27-30)8-18(19)28-22-21-17-3-2-13(6-20(17)34-23(21)26-12-25-22)24(31)29-9-16-7-15(29)11-33-16/h4-5,8,10,12-13,15-16H,2-3,6-7,9,11H2,1H3,(H,25,26,28)/t13-,15-,16-/m0/s1	PDB GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US10487092 (2019) BindingDB Entry DOI: 10.7270/Q28W3GPZ
					More data for this Ligand-Target Pair