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SMILES: Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCC2(CC1)N=N2

InChI Key: InChIKey=XBIDNXSOCMLFBG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 426245   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor 1


(Homo sapiens (Human))		BDBM426245
PNG
(5-(2-(4-Fluorophenyl)-8-(1,2,6-triazaspiro[2;5]oct...)
Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCC2(CC1)N=N2 |c:38|
Show InChI InChI=1S/C25H20FN7O/c26-18-4-1-15(2-5-18)21-22(16-3-6-19-17(13-16)14-20(34)28-19)33-12-9-27-23(24(33)29-21)32-10-7-25(8-11-32)30-31-25/h1-6,9,12-13H,7-8,10-11,14H2,(H,28,34)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.160n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...

US Patent US10513523 (2019)


BindingDB Entry DOI: 10.7270/Q2KW5JDR
More data for this
Ligand-Target Pair