null

SMILES: C[C@@](O)(CO)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=HJVLHGXGDKFDKJ-PQHLKRTFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427118   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427118 ((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES C[C@@](O)(CO)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO7S/c1-28(38,15-35)20-11-23-26(24(33)12-20)30(19-4-7-21(31)8-5-19,41-17-29(16-36)9-10-29)34(27(23)37)14-18-3-6-22(32)13-25(18)42(2,39)40/h3-8,11-13,35-36,38H,9-10,14-17H2,1-2H3/t28-,30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021)
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427118 ((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES C[C@@](O)(CO)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO7S/c1-28(38,15-35)20-11-23-26(24(33)12-20)30(19-4-7-21(31)8-5-19,41-17-29(16-36)9-10-29)34(27(23)37)14-18-3-6-22(32)13-25(18)42(2,39)40/h3-8,11-13,35-36,38H,9-10,14-17H2,1-2H3/t28-,30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair