null

SMILES: CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@@](C)(O)C1CCOCC1)c1ccc(Cl)cc1

InChI Key: InChIKey=AVDHVIXZENQIRS-HOSFBAFGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427147 ((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...) Show SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@@](C)(O)C1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H30Cl2FNO6/c1-30(39,19-11-13-41-14-12-19)21-15-24-28(25(34)16-21)31(40-2,20-5-9-23(33)10-6-20)35(29(24)38)26(17-27(36)37)18-3-7-22(32)8-4-18/h3-10,15-16,19,26,39H,11-14,17H2,1-2H3,(H,36,37)/t26-,30-,31+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021)
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427147 ((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...) Show SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@@](C)(O)C1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H30Cl2FNO6/c1-30(39,19-11-13-41-14-12-19)21-15-24-28(25(34)16-21)31(40-2,20-5-9-23(33)10-6-20)35(29(24)38)26(17-27(36)37)18-3-7-22(32)8-4-18/h3-10,15-16,19,26,39H,11-14,17H2,1-2H3,(H,36,37)/t26-,30-,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair