null

SMILES: CC[C@@](O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=CDUKUNZREUVQKN-FRJUPVQCSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 427156   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427156 (4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...) Show SMILES CC[C@@](O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H30ClFN4O4/c1-3-32(41,29-18-38(2)20-37-29)24-14-27-30(28(35)15-24)33(43-26-12-13-42-19-26,23-8-10-25(34)11-9-23)39(31(27)40)17-22-6-4-21(16-36)5-7-22/h4-11,14-15,18,20,26,41H,3,12-13,17,19H2,1-2H3/t26-,32-,33+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021)
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427156 (4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...) Show SMILES CC[C@@](O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H30ClFN4O4/c1-3-32(41,29-18-38(2)20-37-29)24-14-27-30(28(35)15-24)33(43-26-12-13-42-19-26,23-8-10-25(34)11-9-23)39(31(27)40)17-22-6-4-21(16-36)5-7-22/h4-11,14-15,18,20,26,41H,3,12-13,17,19H2,1-2H3/t26-,32-,33+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair