BDBM4274 2-(1H-imidazol-2-ylmethylidene)propanedinitrile::Tyrphostin deriv. 4

SMILES: N#CC(=Cc1ncc[nH]1)C#N

InChI Key: InChIKey=AYENSJBDZMHPTB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4274   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4274 (2-(1H-imidazol-2-ylmethylidene)propanedinitrile | ...) Show SMILES N#CC(=Cc1ncc[nH]1)C#N |(12.23,-11.09,;12.26,-9.41,;12.28,-7.72,;10.94,-6.96,;9.35,-7.62,;8.87,-6.15,;7.33,-6.16,;6.86,-7.62,;8.11,-8.52,;13.61,-6.93,;14.93,-6.15,)| Show InChI InChI=1S/C7H4N4/c8-4-6(5-9)3-7-10-1-2-11-7/h1-3H,(H,10,11)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.32E+5	n/a	n/a	n/a	n/a	7.6	22
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair