Found 18 hits for monomerid = 427891 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 988 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 988 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 988 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10730877 (2020)
BindingDB Entry DOI: 10.7270/Q2H41VH3 |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 9
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 7
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
HEK-Blue™-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducibl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2S46W4Z |
More data for this
Ligand-Target Pair | |
Toll-like receptor 8
(Homo sapiens (Human)) | BDBM427891
(US10544143, Example 325 | US10544143, Example 326 ...)Show SMILES COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N1CCC1 |(9.15,1.24,;7.61,1.24,;6.84,-.1,;5.3,-.1,;4.53,-1.43,;5.3,-2.76,;6.84,-2.76,;7.87,-3.91,;9.27,-3.28,;9.11,-1.75,;7.61,-1.43,;2.99,-1.43,;2.08,-2.68,;.62,-2.2,;-.72,-2.97,;-2.05,-2.2,;-3.39,-2.97,;-2.05,-.66,;-.72,.11,;.62,-.66,;2.08,-.18,;2.48,1.3,;1.39,2.39,;3.97,1.7,;-3.39,.11,;-4.72,-.66,;-6.05,.11,;-6.05,1.65,;-4.72,2.42,;-3.39,1.65,;-7.39,2.42,;-7.79,3.91,;-9.27,3.51,;-8.87,2.02,)| Show InChI InChI=1S/C27H34N6O/c1-16(2)23-25(19-13-22(34-4)27-28-15-29-33(27)14-19)30-21-12-17(3)24(31-26(21)23)18-6-8-20(9-7-18)32-10-5-11-32/h12-16,18,20,30H,5-11H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible... |
US Patent US10544143 (2020)
BindingDB Entry DOI: 10.7270/Q2QF8W80 |
More data for this
Ligand-Target Pair | |
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